Small-molecule inhibitors of protein-protein interactions

por Vassilev, Lyubomir., Fry, David.
Publicado 2011

Reduced transcriptional activity in the p53 pathway of senescent cells revealed by the MDM2 antagonist nutlin-3

por Huang, Baoying, Vassilev, Lyubomir T.
Publicado 2009

1,25-dihydroxyvitamin D(3) enhances the apoptotic activity of MDM2 antagonist nutlin-3a in acute myeloid leukemia cells expressing wild-type p53

por Thompson, Thelma, Andreeff, Michael, Studzinski, George P., Vassilev, Lyubomir T.
Publicado 2010

Tumor suppressor p53 status does not determine the differentiation-associated G(1) cell cycle arrest induced in leukemia cells by 1,25-dihydroxyvitamin D(3) and antioxidants

por Thompson, Thelma, Danilenko, Michael, Vassilev, Lyubomir, Studzinski, George P
Publicado 2010

Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity

por Ullah, Zakir, Kohn, Matthew J., Yagi, Rieko, Vassilev, Lyubomir T., DePamphilis, Melvin L.
Publicado 2008

DNA-PK Inhibitor, M3814, as a New Combination Partner of Mylotarg in the Treatment of Acute Myeloid Leukemia

por Carr, Michael I., Zimmermann, Astrid, Chiu, Li-Ya, Zenke, Frank T., Blaukat, Andree, Vassilev, Lyubomir T.
Publicado en Front Oncol (2020)

MDM2 antagonists boost antitumor effect of androgen withdrawal: implications for therapy of prostate cancer

por Tovar, Christian, Higgins, Brian, Kolinsky, Kenneth, Xia, Mingxuan, Packman, Kathryn, Heimbrook, David C, Vassilev, Lyubomir T
Publicado 2011

Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1

por Vassilev, Lyubomir T., Tovar, Christian, Chen, Shaoqing, Knezevic, Dejan, Zhao, Xiaolan, Sun, Hongmao, Heimbrook, David C., Chen, Li
Publicado 2006

MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines

por Ohnstad, Hege O, Paulsen, Erik B, Noordhuis, Paul, Berg, Marianne, Lothe, Ragnhild A, Vassilev, Lyubomir T, Myklebost, Ola
Publicado 2011

Protein-protein interactions involved in the recognition of p27 by E3 ubiquitin ligase.

por Xu, Kui, Belunis, Charles, Chu, Wei, Weber, David, Podlaski, Frank, Huang, Kuo-Sen, Reed, Steven I, Vassilev, Lyubomir T
Publicado 2003

Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML

por Carter, Bing Z., Mak, Duncan H., Schober, Wendy D., Koller, Erich, Pinilla, Clemencia, Vassilev, Lyubomir T., Reed, John C., Andreeff, Michael
Publicado 2010

Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5

por Carter, Bing Z., Mak, Duncan H., Schober, Wendy D., Dietrich, Martin F., Pinilla, Clemencia, Vassilev, Lyubomir T., Reed, John C., Andreeff, Michael
Publicado 2008

DNA-PK inhibitor peposertib enhances p53-dependent cytotoxicity of DNA double-strand break inducing therapy in acute leukemia

por Haines, Eric, Nishida, Yuki, Carr, Michael I., Montoya, Rafael Heinz, Ostermann, Lauren B., Zhang, Weiguo, Zenke, Frank T., Blaukat, Andree, Andreeff, Michael, Vassilev, Lyubomir T.
Publicado en Sci Rep (2021)

MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy

por Kojima, Kensuke, Konopleva, Marina, Samudio, Ismael J., Shikami, Masato, Cabreira-Hansen, Maria, McQueen, Teresa, Ruvolo, Vivian, Tsao, Twee, Zeng, Zhihong, Vassilev, Lyubomir T., Andreeff, Michael
Publicado 2005

Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: Implications for therapy

por Tovar, Christian, Rosinski, James, Filipovic, Zoran, Higgins, Brian, Kolinsky, Kenneth, Hilton, Holly, Zhao, Xiaolan, Vu, Binh T., Qing, Weiguo, Packman, Kathryn, Myklebost, Ola, Heimbrook, David C., Vassilev, Lyubomir T.
Publicado 2006

Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development

por Vu, Binh, Wovkulich, Peter, Pizzolato, Giacomo, Lovey, Allen, Ding, Qingjie, Jiang, Nan, Liu, Jin-Jun, Zhao, Chunlin, Glenn, Kelli, Wen, Yang, Tovar, Christian, Packman, Kathryn, Vassilev, Lyubomir, Graves, Bradford
Publicado 2013

Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization

por Graves, Bradford, Thompson, Thelma, Xia, Mingxuan, Janson, Cheryl, Lukacs, Christine, Deo, Dayanand, Di Lello, Paola, Fry, David, Garvie, Colin, Huang, Kuo-Sen, Gao, Lin, Tovar, Christian, Lovey, Allen, Wanner, Jutta, Vassilev, Lyubomir T.
Publicado 2012

Attenuation of Soft-Tissue Sarcomas Resistance to the Cytotoxic Action of TNF-α by Restoring p53 Function

por Muret, Jane, Hasmim, Meriem, Stasik, Izabela, Jalil, Abdelali, Mallavialle, Aude, Nanbakhsh, Arash, Lacroix, Ludovic, Billot, Katy, Baud, Véronique, Thiery, Jérome, Vielh, Philippe, Terrier, Philippe, Wiels, Joelle, Vassilev, Lyubomir, Lecesne, Axel, Bonvalot, Sylvie, Chouaib, Salem
Publicado 2012

Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development

por Zhang, Zhuming, Chu, Xin-Jie, Liu, Jin-Jun, Ding, Qingjie, Zhang, Jing, Bartkovitz, David, Jiang, Nan, Karnachi, Prabha, So, Sung-Sau, Tovar, Christian, Filipovic, Zoran M., Higgins, Brian, Glenn, Kelli, Packman, Kathryn, Vassilev, Lyubomir, Graves, Bradford
Publicado 2013

Constitutive autophagy contributes to resistance to TP53-mediated apoptosis in Epstein-Barr virus-positive latency III B-cell lymphoproliferations

por Pujals, Anaïs, Favre, Loëtitia, Pioche-Durieu, Catherine, Robert, Aude, Meurice, Guillaume, Le Gentil, Marion, Chelouah, Sonia, Martin-Garcia, Nadine, Le Cam, Eric, Guettier, Catherine, Raphaël, Martine, Vassilev, Lyubomir T, Gaulard, Philippe, Codogno, Patrice, Lipinski, Marc, Wiels, Joëlle
Publicado en Autophagy (2015)