MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy

Although TP53 mutations are rare in acute myeloid leukemia (AML), inactivation of wild-type p53 protein frequently occurs through overexpression of its negative regulator MDM2 (murine double minute 2). Recently, small-molecule antagonists of MDM2, Nutlins, have been developed that inhibit the p53-MD...

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Autors principals: Kojima, Kensuke, Konopleva, Marina, Samudio, Ismael J., Shikami, Masato, Cabreira-Hansen, Maria, McQueen, Teresa, Ruvolo, Vivian, Tsao, Twee, Zeng, Zhihong, Vassilev, Lyubomir T., Andreeff, Michael
Format: Artigo
Idioma:Inglês
Publicat: The American Society of Hematology 2005
Matèries:
Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895324/
https://ncbi.nlm.nih.gov/pubmed/16014563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-02-0553
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