Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia

Aberrant expression of Aurora kinases and inactivation of wild-type p53 by Mdm2 overexpression are frequent molecular events in acute myelogenous leukemia (AML), and preclinical data for inhibition of Aurora kinases or Mdm2 are promising. However, it remains largely unknown whether the viability of...

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Detalhes bibliográficos
Main Authors: Kojima, Kensuke, Konopleva, Marina, Tsao, Twee, Nakakuma, Hideki, Andreeff, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556624/
https://ncbi.nlm.nih.gov/pubmed/18633130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-01-128611
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