Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia

Aberrant expression of Aurora kinases and inactivation of wild-type p53 by Mdm2 overexpression are frequent molecular events in acute myelogenous leukemia (AML), and preclinical data for inhibition of Aurora kinases or Mdm2 are promising. However, it remains largely unknown whether the viability of...

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Hlavní autoři: Kojima, Kensuke, Konopleva, Marina, Tsao, Twee, Nakakuma, Hideki, Andreeff, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2008
Témata:
Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556624/
https://ncbi.nlm.nih.gov/pubmed/18633130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-01-128611
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