Concomitant inhibition of DNA methyltransferase and BCL-2 protein function synergistically induce mitochondrial apoptosis in acute myelogenous leukemia cells

DNA methylation and BLC-2 are potential therapeutic targets in acute myeloid leukemia (AML). We investigated pharmacologic interaction between the DNA methyltransferase inhibitor 5-azacytidine (5-AZA) and the BCL-2 inhibitor ABT-737. Increased BCL-2 expression determined by reverse phase protein ana...

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Hoofdauteurs: Tsao, Twee, Shi, Yuexi, Kornblau, Steven, Lu, Hongbo, Konoplev, Sergej, Antony, Ansu, Ruvolo, Vivian, Qiu, Yi Hua, Zhang, Ninaxiang, Coombes, Kevin R., Andreeff, Michael, Kojima, Kensuke, Konopleva, Marina
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750747/
https://ncbi.nlm.nih.gov/pubmed/22893484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00277-012-1537-8
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