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Decreased sensitivity of 17p-deleted chronic lymphocytic leukemia cells to a small molecule BCL-2 antagonist ABT-737
BACKGROUND: Despite the high complete response rates with fludarabine-based regimens, relapse is inevitable in chronic lymphocytic leukemia (CLL). Relapsed patients often acquire 17p deletions [del(17p)], which are closely associated with TP53 mutations. Wild-type p53 upregulates and activates BAX,...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3579224/ https://ncbi.nlm.nih.gov/pubmed/21761401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.26360 |
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