PI3K inhibitor GDC-0941 enhances apoptotic effects of BH-3 mimetic ABT-737 in AML cells in the hypoxic bone marrow microenvironment

Both phosphatidylinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling and antiapoptotic Bcl-2 family members are critical for survival of acute myeloid leukemia (AML) cells. Here we demonstrate the antileukemic effects of simultaneous inhibition of PI3K by the selective class...

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Hauptverfasser: Jin, Linhua, Tabe, Yoko, Kojima, Kensuke, Shikami, Masato, Benito, Julina, Ruvolo, Vivian, Wang, Rui-Yu, McQueen, Teresa, Ciurea, Stefan O., Miida, Takashi, Andreeff, Michael, Konopleva, Marina
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834093/
https://ncbi.nlm.nih.gov/pubmed/23955073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-013-1076-3
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