The BH3 Mimetic ABT-737 Induces Cancer Cell Senescence

ABT-737, a small molecule cell-permeable Bcl-2 antagonist that acts by mimicking BH3 proteins, induces apoptotic cell death in multiple cancer types. However, when incubated with this agent many solid tumor cell lines do not undergo apoptosis. The current study reveals a novel mechanism whereby ABT-...

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Bibliographic Details
Main Authors: Song, Jin H., Kandasamy, Karthikeyan, Zemskova, Marina, Lin, Ying-Wei, Kraft, Andrew S.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3459262/
https://ncbi.nlm.nih.gov/pubmed/21084274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-1977
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