Sensitization of BCL-2–expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737

Overexpression of the prosurvival protein BCL-2 is common in breast cancer. Here we have explored its role as a potential therapeutic target in this disease. BCL-2, its anti-apoptotic relatives MCL-1 and BCL-XL, and the proapoptotic BH3-only ligand BIM were found to be coexpressed at relatively high...

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Bibliografische gegevens
Hoofdauteurs: Oakes, Samantha R., Vaillant, François, Lim, Elgene, Lee, Lily, Breslin, Kelsey, Feleppa, Frank, Deb, Siddhartha, Ritchie, Matthew E., Takano, Elena, Ward, Teresa, Fox, Stephen B., Generali, Daniele, Smyth, Gordon K., Strasser, Andreas, Huang, David C. S., Visvader, Jane E., Lindeman, Geoffrey J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2012
Onderwerpen:
Breast Cancer Special Feature
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286989/
https://ncbi.nlm.nih.gov/pubmed/21768359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104778108
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