Sensitization of BCL-2–expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737

Overexpression of the prosurvival protein BCL-2 is common in breast cancer. Here we have explored its role as a potential therapeutic target in this disease. BCL-2, its anti-apoptotic relatives MCL-1 and BCL-XL, and the proapoptotic BH3-only ligand BIM were found to be coexpressed at relatively high...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Oakes, Samantha R., Vaillant, François, Lim, Elgene, Lee, Lily, Breslin, Kelsey, Feleppa, Frank, Deb, Siddhartha, Ritchie, Matthew E., Takano, Elena, Ward, Teresa, Fox, Stephen B., Generali, Daniele, Smyth, Gordon K., Strasser, Andreas, Huang, David C. S., Visvader, Jane E., Lindeman, Geoffrey J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
Soggetti:
Breast Cancer Special Feature
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286989/
https://ncbi.nlm.nih.gov/pubmed/21768359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104778108
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi