Sensitization of BCL-2–expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737

Overexpression of the prosurvival protein BCL-2 is common in breast cancer. Here we have explored its role as a potential therapeutic target in this disease. BCL-2, its anti-apoptotic relatives MCL-1 and BCL-XL, and the proapoptotic BH3-only ligand BIM were found to be coexpressed at relatively high...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Oakes, Samantha R., Vaillant, François, Lim, Elgene, Lee, Lily, Breslin, Kelsey, Feleppa, Frank, Deb, Siddhartha, Ritchie, Matthew E., Takano, Elena, Ward, Teresa, Fox, Stephen B., Generali, Daniele, Smyth, Gordon K., Strasser, Andreas, Huang, David C. S., Visvader, Jane E., Lindeman, Geoffrey J.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
Breast Cancer Special Feature
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286989/
https://ncbi.nlm.nih.gov/pubmed/21768359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104778108
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars