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Sensitization of BCL-2–expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737
Overexpression of the prosurvival protein BCL-2 is common in breast cancer. Here we have explored its role as a potential therapeutic target in this disease. BCL-2, its anti-apoptotic relatives MCL-1 and BCL-XL, and the proapoptotic BH3-only ligand BIM were found to be coexpressed at relatively high...
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| Autors principals: | , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3286989/ https://ncbi.nlm.nih.gov/pubmed/21768359 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104778108 |
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