Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development

[Image: see text] The p53 tumor suppressor is a potent transcription factor that plays a key role in the regulation of cellular responses to stress. It is controlled by its negative regulator MDM2, which binds directly to p53 and inhibits its transcriptional activity. MDM2 also targets p53 for degra...

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Detalhes bibliográficos
Main Authors: Vu, Binh, Wovkulich, Peter, Pizzolato, Giacomo, Lovey, Allen, Ding, Qingjie, Jiang, Nan, Liu, Jin-Jun, Zhao, Chunlin, Glenn, Kelli, Wen, Yang, Tovar, Christian, Packman, Kathryn, Vassilev, Lyubomir, Graves, Bradford
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027145/
https://ncbi.nlm.nih.gov/pubmed/24900694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml4000657
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