Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development

[Image: see text] The p53 tumor suppressor is a potent transcription factor that plays a key role in the regulation of cellular responses to stress. It is controlled by its negative regulator MDM2, which binds directly to p53 and inhibits its transcriptional activity. MDM2 also targets p53 for degra...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Vu, Binh, Wovkulich, Peter, Pizzolato, Giacomo, Lovey, Allen, Ding, Qingjie, Jiang, Nan, Liu, Jin-Jun, Zhao, Chunlin, Glenn, Kelli, Wen, Yang, Tovar, Christian, Packman, Kathryn, Vassilev, Lyubomir, Graves, Bradford
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Chemical Society 2013
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027145/
https://ncbi.nlm.nih.gov/pubmed/24900694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml4000657
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