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Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: Implications for therapy
The p53 tumor suppressor retains its wild-type conformation and transcriptional activity in half of all human tumors, and its activation may offer a therapeutic benefit. However, p53 function could be compromised by defective signaling in the p53 pathway. Using a small-molecule MDM2 antagonist, nutl...
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| Main Authors: | , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1413632/ https://ncbi.nlm.nih.gov/pubmed/16443686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507493103 |
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