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1,25-dihydroxyvitamin D(3) enhances the apoptotic activity of MDM2 antagonist nutlin-3a in acute myeloid leukemia cells expressing wild-type p53
The tumor suppressor p53 is often referred to as ‘the guardian of the genome’ due to its central role in the cellular response to oncogenic stress and prevention of tumor development. Mutations of p53 in acute myeloid leukemia are rare but resistance to chemotherapy has been reported due to deregula...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2868102/ https://ncbi.nlm.nih.gov/pubmed/20406950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-1036 |
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