The MDM-2 Antagonist Nutlin-3 Promotes the Maturation of Acute Myeloid Leukemic Blasts

The small-molecule inhibitor of murine double minute (MDM-2), Nutlin-3, induced variable apoptosis in primary acute myeloid leukemia (AML) blasts and promoted myeloid maturation of surviving cells, as demonstrated by analysis of CD11b and CD14 surface antigens and by morphologic examination. Althoug...

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Detalhes bibliográficos
Main Authors: Secchiero, Paola, Zerbinati, Carlotta, Melloni, Elisabetta, Milani, Daniela, Campioni, Diana, Fadda, Roberto, Tiribelli, Mario, Zauli, Giorgio
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040212/
https://ncbi.nlm.nih.gov/pubmed/17971905
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