The MDM-2 Antagonist Nutlin-3 Promotes the Maturation of Acute Myeloid Leukemic Blasts

The small-molecule inhibitor of murine double minute (MDM-2), Nutlin-3, induced variable apoptosis in primary acute myeloid leukemia (AML) blasts and promoted myeloid maturation of surviving cells, as demonstrated by analysis of CD11b and CD14 surface antigens and by morphologic examination. Althoug...

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Autors principals: Secchiero, Paola, Zerbinati, Carlotta, Melloni, Elisabetta, Milani, Daniela, Campioni, Diana, Fadda, Roberto, Tiribelli, Mario, Zauli, Giorgio
Format: Artigo
Idioma:Inglês
Publicat: Neoplasia Press Inc. 2007
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040212/
https://ncbi.nlm.nih.gov/pubmed/17971905
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