The MDM-2 Antagonist Nutlin-3 Promotes the Maturation of Acute Myeloid Leukemic Blasts

The small-molecule inhibitor of murine double minute (MDM-2), Nutlin-3, induced variable apoptosis in primary acute myeloid leukemia (AML) blasts and promoted myeloid maturation of surviving cells, as demonstrated by analysis of CD11b and CD14 surface antigens and by morphologic examination. Althoug...

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Autori principali: Secchiero, Paola, Zerbinati, Carlotta, Melloni, Elisabetta, Milani, Daniela, Campioni, Diana, Fadda, Roberto, Tiribelli, Mario, Zauli, Giorgio
Natura: Artigo
Lingua:Inglês
Pubblicazione: Neoplasia Press Inc. 2007
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040212/
https://ncbi.nlm.nih.gov/pubmed/17971905
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