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MRx102, a triptolide derivative, has potent antileukemic activity in vitro and in a murine model of AML
Triptolide, isolated from the herb Tripterygium wilfordii, has been shown to potently induce apoptosis in various malignant cells by inhibiting RNA synthesis and NF-κB activity. Previously, we showed that triptolide promotes apoptosis in acute myeloid leukemia (AML) cells via the mitochondria-mediat...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3598158/ https://ncbi.nlm.nih.gov/pubmed/21904380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.246 |
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