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Preclinical antileukemic activity, toxicology, toxicokinetics and formulation development of triptolide derivative MRx102
PURPOSE: Triptolide induces cancer cell apoptosis by inhibiting RNA synthesis and signaling pathways like NF-κB. We compared triptolide prodrug MRx102 to triptolide to determine if it displayed comparable efficacy and improved toxicology and toxicokinetic profiles. METHODS: MV4–11 AML cells and cell...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4091685/ https://ncbi.nlm.nih.gov/pubmed/24619497 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-014-2428-6 |
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