Regulation of survivin expression through Bcr-Abl/MAPK cascade: targeting survivin overcomes imatinib resistance and increases imatinib sensitivity in imatinib-responsive CML cells

KBM5 cells, derived from a patient with blast crisis Philadelphia chromosome-positive (Ph(+)) chronic myelogenous leukemia (CML), and imatinib-resistant KBM5 (KBM5-STI571) cells were found to express high levels of survivin. Inhibition of Bcr-Abl by imatinib significantly decreased survivin expressi...

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Autores principales: Carter, Bing Z., Mak, Duncan H., Schober, Wendy D., Cabreira-Hansen, Maria, Beran, Miloslav, McQueen, Teresa, Chen, Wenjing, Andreeff, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: © 2006 by The American Society of Hematology 2006
Materias:
Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895411/
https://ncbi.nlm.nih.gov/pubmed/16254145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-12-4704
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