Sensitivity of imatinib-resistant T315I BCR-ABL CML to a synergistic combination of ponatinib and forskolin treatment

Tyrosine kinase inhibitors (TKIs) have dramatically improved the life expectancy of patients suffering from chronic myeloid leukemia (CML); however, patients will eventually develop resistance to TKI therapy or adverse side effects due to secondary off-target mechanisms associated with TKIs. CML pat...

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Bibliographische Detailangaben
Veröffentlicht in:Tumour Biol
Hauptverfasser: Oaxaca, Derrick M., Yang-Reid, Sun Ah, Ross, Jeremy A., Rodriguez, Georgialina, Staniswalis, Joan G., Kirken, Robert A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Netherlands 2016
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5080333/
https://ncbi.nlm.nih.gov/pubmed/27444277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13277-016-5179-7
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