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Regulation of survivin expression through Bcr-Abl/MAPK cascade: targeting survivin overcomes imatinib resistance and increases imatinib sensitivity in imatinib-responsive CML cells
KBM5 cells, derived from a patient with blast crisis Philadelphia chromosome-positive (Ph(+)) chronic myelogenous leukemia (CML), and imatinib-resistant KBM5 (KBM5-STI571) cells were found to express high levels of survivin. Inhibition of Bcr-Abl by imatinib significantly decreased survivin expressi...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
© 2006 by The American Society of Hematology
2006
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1895411/ https://ncbi.nlm.nih.gov/pubmed/16254145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-12-4704 |
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