Activation of Apoptosis Signaling Eliminates CD34(+) Progenitor Cells in Blast Crisis CML Independent of Response to Tyrosine Kinase Inhibitors

Despite being highly effective for newly diagnosed chronic myeloid leukemia (CML), imatinib not only is inactive against quiescent CML stem cells, but also has limited activity against blast crisis (BC) CML. The relative activity of Bcr-Abl and the expression levels of antiapoptotic proteins in prol...

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Autores principales: Mak, Duncan H., Wang, Rui-Yu, Schober, Wendy D., Konopleva, Marina, Cortes, Jorge, Kantarjian, Hagop, Andreeff, Michael, Carter, Bing Z.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3598156/
https://ncbi.nlm.nih.gov/pubmed/22033489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.285
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