Activation of Apoptosis Signaling Eliminates CD34(+) Progenitor Cells in Blast Crisis CML Independent of Response to Tyrosine Kinase Inhibitors

Despite being highly effective for newly diagnosed chronic myeloid leukemia (CML), imatinib not only is inactive against quiescent CML stem cells, but also has limited activity against blast crisis (BC) CML. The relative activity of Bcr-Abl and the expression levels of antiapoptotic proteins in prol...

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Detalhes bibliográficos
Main Authors: Mak, Duncan H., Wang, Rui-Yu, Schober, Wendy D., Konopleva, Marina, Cortes, Jorge, Kantarjian, Hagop, Andreeff, Michael, Carter, Bing Z.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3598156/
https://ncbi.nlm.nih.gov/pubmed/22033489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.285
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