Synergistic effects of p53 activation via MDM2 inhibition in combination with inhibition of Bcl-2 or Bcr-Abl in CD34(+) proliferating and quiescent chronic myeloid leukemia blast crisis cells

The Bcr-Abl tyrosine kinase regulates several Bcl-2 family proteins that confer resistance to apoptosis in chronic myeloid leukemia (CML) cells. Given p53's ability to modulate the expression and activity of Bcl-2 family members, we hypothesized that targeting Bcr-Abl, Bcl-2, and p53 concomitan...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Carter, Bing Z., Mak, Po Yee, Mak, Duncan H., Ruvolo, Vivian R., Schober, Wendy, McQueen, Teresa, Cortes, Jorge, Kantarjian, Hagop M., Champlin, Richard E., Konopleva, Marina, Andreeff, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
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Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741546/
https://ncbi.nlm.nih.gov/pubmed/26431162
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