Combined inhibition of β-catenin and Bcr–Abl synergistically targets tyrosine kinase inhibitor-resistant blast crisis chronic myeloid leukemia blasts and progenitors in vitro and in vivo

Tyrosine kinase inhibitor (TKI) resistance and progression to blast crisis (BC), both related to persistent β-catenin activation, remain formidable challenges for chronic myeloid leukemia (CML). We observed overexpression of β-catenin in BC-CML stem/progenitor cells, particularly in granulocyte–macr...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Zhou, H, Mak, P Y, Mu, H, Mak, D H, Zeng, Z, Cortes, J, Liu, Q, Andreeff, M, Carter, B Z
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628102/
https://ncbi.nlm.nih.gov/pubmed/28321124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.87
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