Activation of Apoptosis Signaling Eliminates CD34(+) Progenitor Cells in Blast Crisis CML Independent of Response to Tyrosine Kinase Inhibitors

Despite being highly effective for newly diagnosed chronic myeloid leukemia (CML), imatinib not only is inactive against quiescent CML stem cells, but also has limited activity against blast crisis (BC) CML. The relative activity of Bcr-Abl and the expression levels of antiapoptotic proteins in prol...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Mak, Duncan H., Wang, Rui-Yu, Schober, Wendy D., Konopleva, Marina, Cortes, Jorge, Kantarjian, Hagop, Andreeff, Michael, Carter, Bing Z.
Format: Artigo
Langue:Inglês
Publié: 2011
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3598156/
https://ncbi.nlm.nih.gov/pubmed/22033489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.285
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires