BRD4 facilitates replication stress-induced DNA damage response

Previous reports have demonstrated that select cancers depend on BRD4 to regulate oncogenic gene transcriptional programs. Here, we describe a novel role for BRD4 in DNA damage response (DDR). BRD4 associates with and regulates the function of pre-replication factor CDC6 and plays an indispensable p...

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Publicado no:Oncogene
Main Authors: Zhang, Jingwen, Dulak, Austin M., Hattersley, Maureen M., Willis, Brandon S., Nikkilä, Jenni, Wang, Anderson, Lau, Alan, Reimer, Corinne, Zinda, Michael, Fawell, Stephen E., Mills, Gordon B., Chen, Huawei
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6101970/
https://ncbi.nlm.nih.gov/pubmed/29636547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0194-3
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