BRD4 facilitates DNA damage response and represses CBX5/Heterochromatin protein 1 (HP1)

Ovarian cancer (OC) is a heterogeneous disease characterized by defective DNA repair. Very few targets are universally expressed in the high grade serous (HGS) subtype. We previously identified that CHK1 was overexpressed in most of HGSOC. Here, we sought to understand the DNA damage response (DDR)...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Pongas, Georgios, Kim, Marianne K., Min, Dong J., House, Carrie D., Jordan, Elizabeth, Caplen, Natasha, Chakka, Sirisha, Ohiri, Joyce, Kruhlak, Michael J., Annunziata, Christina M.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584257/
https://ncbi.nlm.nih.gov/pubmed/28881656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17572
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