BRD4 facilitates DNA damage response and represses CBX5/Heterochromatin protein 1 (HP1)

Ovarian cancer (OC) is a heterogeneous disease characterized by defective DNA repair. Very few targets are universally expressed in the high grade serous (HGS) subtype. We previously identified that CHK1 was overexpressed in most of HGSOC. Here, we sought to understand the DNA damage response (DDR)...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncotarget
Prif Awduron: Pongas, Georgios, Kim, Marianne K., Min, Dong J., House, Carrie D., Jordan, Elizabeth, Caplen, Natasha, Chakka, Sirisha, Ohiri, Joyce, Kruhlak, Michael J., Annunziata, Christina M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2017
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584257/
https://ncbi.nlm.nih.gov/pubmed/28881656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17572
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