BRD4 facilitates DNA damage response and represses CBX5/Heterochromatin protein 1 (HP1)

Ovarian cancer (OC) is a heterogeneous disease characterized by defective DNA repair. Very few targets are universally expressed in the high grade serous (HGS) subtype. We previously identified that CHK1 was overexpressed in most of HGSOC. Here, we sought to understand the DNA damage response (DDR)...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Pongas, Georgios, Kim, Marianne K., Min, Dong J., House, Carrie D., Jordan, Elizabeth, Caplen, Natasha, Chakka, Sirisha, Ohiri, Joyce, Kruhlak, Michael J., Annunziata, Christina M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584257/
https://ncbi.nlm.nih.gov/pubmed/28881656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17572
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