Evidence of mTOR Activation by an AKT-Independent Mechanism Provides Support for the Combined Treatment of PTEN-Deficient Prostate Tumors with mTOR and AKT Inhibitors

Activation of the phosphoinositide 3-kinase pathway is commonly observed in human prostate cancer. Loss of function of phosphatase and tensin homolog (PTEN) is associated with the activation of AKT and mammalian target of rapamycin (mTOR) in many cancer cell lines as well as in other model systems....

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Autores principales: Zhang, Weisheng, Haines, Brian B, Efferson, Clay, Zhu, Joe, Ware, Chris, Kunii, Kaiko, Tammam, Jennifer, Angagaw, Minilik, Hinton, Marlene C, Keilhack, Heike, Paweletz, Cloud P, Zhang, Theresa, Winter, Chris, Sathyanarayanan, Sriram, Cheng, Jonathan, Zawel, Leigh, Fawell, Stephen, Gilliland, Gary, Majumder, Pradip K
Formato: Artigo
Lenguaje:Inglês
Publicado: Neoplasia Press Inc. 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542838/
https://ncbi.nlm.nih.gov/pubmed/23323157
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