FKBPs and the Akt/mTOR pathway

FK506-binding proteins (FKBP) belong to the immunophilin family and are best known for their ability to enable the immunosuppressive properties of FK506 and rapamycin. For rapamycin, this is achieved by inducing inhibitory ternary complexes with the kinase mTOR. The essential accessory protein for t...

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Bibliographic Details
Main Authors: Hausch, Felix, Kozany, Christian, Theodoropoulou, Marily, Fabian, Anne-Katrin
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2013
Subjects:
Perspective
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3841315/
https://ncbi.nlm.nih.gov/pubmed/23839048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.25508
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