Combinatorial interactions of two amino acids with a single base pair define target site specificity in plant dimeric homeodomain proteins

Autor Tron, Adriana E., Bertoncini, Carlos W., Palena, Claudia M., Chan, Raquel L., Gonzalez, Daniel H.
Vydáno 2001

SCF(β-TRCP) targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration

Autor Zhong, Jiateng, Shaik, Shavali, Wan, Lixin, Tron, Adriana E., Wang, Zhiwei, Sun, Liankun, Inuzuka, Hiroyuki, Wei, Wenyi
Vydáno 2013

Pim kinase inhibition sensitizes FLT3-ITD acute myeloid leukemia cells to topoisomerase 2 inhibitors through increased DNA damage and oxidative stress

Autor Doshi, Kshama A., Trotta, Rossana, Natarajan, Karthika, Rassool, Feyruz V., Tron, Adriana E., Huszar, Dennis, Perrotti, Danilo, Baer, Maria R.
Vydáno v Oncotarget (2016)

Structure of a Glomulin-RBX1-CUL1 complex: inhibition of a RING E3 ligase through masking of its E2-binding surface

Autor Duda, David M., Olszewski, Jennifer L., Tron, Adriana E., Hammel, Michal, Lambert, Lester J., Waddell, M. Brett, Mittag, Tanja, DeCaprio, James A., Schulman, Brenda A.
Vydáno 2012

The Glomuvenous Malformation Protein Glomulin Binds Rbx1 and Regulates Cullin RING Ligase-Mediated Turnover of Fbw7

Autor Tron, Adriana E., Arai, Takehiro, Duda, David M., Kuwabara, Hiroshi, Olszewski, Jennifer L., Fujiwara, Yuko, Bahamon, Brittany N., Signoretti, Sabina, Schulman, Brenda A., DeCaprio, James A.
Vydáno 2012

Multiscale Model Identifies Improved Schedule for Treatment of Acute Myeloid Leukemia In Vitro With the Mcl‐1 Inhibitor AZD5991

Autor Goliaei, Ardeshir, Woods, Haley A., Tron, Adriana E., Belmonte, Matthew A., Secrist, J. Paul, Ferguson, Douglas, Drew, Lisa, Fretland, Adrian J., Aldridge, Bree B., Gibbons, Francis D.
Vydáno v CPT Pharmacometrics Syst Pharmacol (2020)

Concurrent inhibition of Pim and FLT3 kinases enhances apoptosis of FLT3-ITD acute myeloid leukemia cells through increased Mcl-1 proteasomal degradation

Autor Kapoor, Shivani, Natarajan, Karthika, Baldwin, Patrick R., Doshi, Kshama A., Lapidus, Rena G., Mathias, Trevor J., Scarpa, Mario, Trotta, Rossana, Davila, Eduardo, Kraus, Manfred, Huszar, Dennis, Tron, Adriana E., Perrotti, Danilo, Baer, Maria R.
Vydáno v Clin Cancer Res (2017)

Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies

Autor Montero, Joan, Gstalder, Cécile, Kim, Daniel J., Sadowicz, Dorota, Miles, Wayne, Manos, Michael, Cidado, Justin R., Paul Secrist, J., Tron, Adriana E., Flaherty, Keith, Stephen Hodi, F., Yoon, Charles H., Letai, Anthony, Fisher, David E., Haq, Rizwan
Vydáno v Nat Commun (2019)

Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction

Autor Gao, Daming, Wan, Lixin, Inuzuka, Hiroyuki, Berg, Anders H., Tseng, Alan, Zhai, Bo, Shaik, Shavali, Bennett, Eric, Tron, Adriana E., Gasser, Jessica A., Lau, Alan, Gygi, Steven, Harper, J. Wade, DeCaprio, James A., Toker, Alex, Wei, Wenyi
Vydáno 2010

Negative Regulation of the Stability and Tumor Suppressor Function of Fbw7 by the Pin1 Prolyl Isomerase

Autor Min, Sang-Hyun, Lau, Alan W., Lee, Tae Ho, Inuzuka, Hiroyuki, Wei, Shuo, Huang, Pengyu, Shaik, Shavali, Lee, Daniel Yenhong, Finn, Greg, Balastik, Martin, Chen, Chun-Hau, Luo, Manli, Tron, Adriana E., DeCaprio, James A., Zhou, Xiao Zhen, Wei, Wenyi, Lu, Kun Ping
Vydáno 2012

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

Autor Tron, Adriana E., Belmonte, Matthew A., Adam, Ammar, Aquila, Brian M., Boise, Lawrence H., Chiarparin, Elisabetta, Cidado, Justin, Embrey, Kevin J., Gangl, Eric, Gibbons, Francis D., Gregory, Gareth P., Hargreaves, David, Hendricks, J. Adam, Johannes, Jeffrey W., Johnstone, Ricky W., Kazmirski, Steven L., Kettle, Jason G., Lamb, Michelle L., Matulis, Shannon M., Nooka, Ajay K., Packer, Martin J., Peng, Bo, Rawlins, Philip B., Robbins, Daniel W., Schuller, Alwin G., Su, Nancy, Yang, Wenzhan, Ye, Qing, Zheng, Xiaolan, Secrist, J. Paul, Clark, Edwin A., Wilson, David M., Fawell, Stephen E., Hird, Alexander W.
Vydáno v Nat Commun (2018)