Pim kinase inhibition sensitizes FLT3-ITD acute myeloid leukemia cells to topoisomerase 2 inhibitors through increased DNA damage and oxidative stress

Internal tandem duplication of fms-like tyrosine kinase-3 (FLT3-ITD) is frequent (30 percent) in acute myeloid leukemia (AML), and is associated with short disease-free survival following chemotherapy. The serine threonine kinase Pim-1 is a pro-survival oncogene transcriptionally upregulated by FLT3...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Foilsithe in:Oncotarget
Main Authors: Doshi, Kshama A., Trotta, Rossana, Natarajan, Karthika, Rassool, Feyruz V., Tron, Adriana E., Huszar, Dennis, Perrotti, Danilo, Baer, Maria R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2016
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217017/
https://ncbi.nlm.nih.gov/pubmed/27374090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10209
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla