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Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia
Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) is frequently detected in acute myeloid leukemia (AML) patients and is associated with a dismal long-term prognosis. FLT3 tyrosine kinase inhibitors provide short-term disease control, but relapse invariably occurs within months. Pim...
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出版年: | Sci Adv |
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主要な著者: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
American Association for the Advancement of Science
2015
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4643770/ https://ncbi.nlm.nih.gov/pubmed/26601252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1500221 |
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