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Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia

Cancer cells require nutrients and energy to adapt to increased biosynthetic activity, and protein synthesis inhibition downstream of mammalian target of rapamycin complex 1 (mTORC1) has shown promise as a possible therapy for acute myeloid leukemia (AML). Glutamine contributes to leucine import int...

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Detalhes bibliográficos
Main Authors: Willems, Lise, Jacque, Nathalie, Jacquel, Arnaud, Neveux, Nathalie, Trovati Maciel, Thiago, Lambert, Mireille, Schmitt, Alain, Poulain, Laury, Green, Alexa S., Uzunov, Madalina, Kosmider, Olivier, Radford-Weiss, Isabelle, Moura, Ivan Cruz, Auberger, Patrick, Ifrah, Norbert, Bardet, Valérie, Chapuis, Nicolas, Lacombe, Catherine, Mayeux, Patrick, Tamburini, Jérôme, Bouscary, Didier
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829119/
https://ncbi.nlm.nih.gov/pubmed/24014241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-03-493163
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