Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition

Cancer cells require glutamine to adapt to increased biosynthetic activity. The limiting step in intracellular glutamine catabolism involves its conversion to glutamate by glutaminase (GA). Different GA isoforms are encoded by the genes GLS1 and GLS2 in humans. Herein, we show that glutamine levels...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Blood
Main Authors: Jacque, Nathalie, Ronchetti, Anne Marie, Larrue, Clément, Meunier, Godelieve, Birsen, Rudy, Willems, Lise, Saland, Estelle, Decroocq, Justine, Maciel, Thiago Trovati, Lambert, Mireille, Poulain, Laury, Hospital, Marie Anne, Sujobert, Pierre, Joseph, Laure, Chapuis, Nicolas, Lacombe, Catherine, Moura, Ivan Cruz, Demo, Susan, Sarry, Jean Emmanuel, Recher, Christian, Mayeux, Patrick, Tamburini, Jérôme, Bouscary, Didier
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4608389/
https://ncbi.nlm.nih.gov/pubmed/26186940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-01-621870
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados