CDC25A governs proliferation and differentiation of FLT3-ITD acute myeloid leukemia

We investigated cell cycle regulation in acute myeloid leukemia cells expressing the FLT3-ITD mutated tyrosine kinase receptor, an underexplored field in this disease. Upon FLT3 inhibition, CDC25A mRNA and protein were rapidly down-regulated, while levels of other cell cycle proteins remained unchan...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Bertoli, Sarah, Boutzen, Helena, David, Laure, Larrue, Clément, Vergez, François, Fernandez-Vidal, Anne, Yuan, Lingli, Hospital, Marie-Anne, Tamburini, Jérôme, Demur, Cécile, Delabesse, Eric, Saland, Estelle, Sarry, Jean-Emmanuel, Galcera, Marie-Odile, Mas, Véronique Mansat-De, Didier, Christine, Dozier, Christine, Récher, Christian, Manenti, Stéphane
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741984/
https://ncbi.nlm.nih.gov/pubmed/26515730
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