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Oncogenic FLT3-ITD supports autophagy via ATF4 in acute myeloid leukemia
In acute myeloid leukemia (AML), internal tandem duplication mutations in the FLT3 tyrosine kinase receptor (FLT3-ITD) account for up to 25% of cases and are associated with a poor outcome. In order to better target this AML subtype, a comprehensive view of how FLT3-ITD impacts AML cell biology is r...
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| Publicado no: | Oncogene |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5808073/ https://ncbi.nlm.nih.gov/pubmed/29059168 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.376 |
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