Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia

The PI3K/AKT and mTOR signaling pathways are activated in acute myeloid leukemia, including in the more immature leukemic populations. Constitutive PI3K activation is detectable in 50% of acute myeloid leukemia samples whereas mTORC1 is activated in all cases of this disease. In leukemic cells, the...

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Detalhes bibliográficos
Main Authors: Park, Sophie, Chapuis, Nicolas, Tamburini, Jérôme, Bardet, Valérie, Cornillet-Lefebvre, Pascale, Willems, Lise, Green, Alexa, Mayeux, Patrick, Lacombe, Catherine, Bouscary, Didier
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2010
Assuntos:
Review Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864389/
https://ncbi.nlm.nih.gov/pubmed/19951971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2009.013797
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