Autocrine IGF-1/IGF-1R signaling is responsible for constitutive PI3K/Akt activation in acute myeloid leukemia: therapeutic value of neutralizing anti-IGF-1R antibody

BACKGROUND: Alterations in the PI3K/Akt pathway are found in a wide range of cancers and the development of PI3K inhibitors represents a promising approach to cancer therapy. Constitutive PI3K activation, reflecting an intrinsic oncogenic deregulation of primary blast cells, is detected in 50% of pa...

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Detalhes bibliográficos
Main Authors: Chapuis, Nicolas, Tamburini, Jérôme, Cornillet-Lefebvre, Pascale, Gillot, Lucile, Bardet, Valérie, Willems, Lise, Park, Sophie, Green, Alexa S, Ifrah, Norbert, Dreyfus, François, Mayeux, Patrick, Lacombe, Catherine, Bouscary, Didier
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2833071/
https://ncbi.nlm.nih.gov/pubmed/20007139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2009.010785
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