Autocrine IGF-1 Action in Adipocytes Controls Systemic IGF-1 Concentrations and Growth

OBJECTIVE—IGF-1 and the IGF-1 receptor (IGF-1R) have been implicated in the regulation of adipocyte differentiation and lipid accumulation in vitro. RESEARCH DESIGN AND METHODS—To investigate the role of IGF-1 receptor in vivo, we have inactivated the Igf-1r gene in adipose tissue (IGF-1R(aP2Cre) mi...

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書誌詳細
主要な著者: Klöting, Nora, Koch, Linda, Wunderlich, Thomas, Kern, Matthias, Ruschke, Karen, Krone, Wilhelm, Brüning, Jens C., Blüher, Matthias
フォーマット: Artigo
言語:Inglês
出版事項: American Diabetes Association 2008
主題:
Signal Transduction
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494689/
https://ncbi.nlm.nih.gov/pubmed/18443199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db07-1538
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