CCL5 mediates target‐kinase independent resistance to FLT3 inhibitors in FLT3‐ITD‐positive AML

FLT3‐ITD tyrosine kinase inhibitors (TKI) show limited clinical activity in acute myeloid leukemia (AML) due to emerging resistance. TKI resistance is mediated by secondary FLT3‐ITD mutations only in a minority of cases. We hypothesize that the cytokine CCL5 protects AML cells from TKI‐mediated cell...

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發表在:Mol Oncol
Main Authors: Waldeck, Silvia, Rassner, Michael, Keye, Philip, Follo, Marie, Herchenbach, Dieter, Endres, Cornelia, Charlet, Anne, Andrieux, Geoffroy, Salzer, Ulrich, Boerries, Melanie, Duyster, Justus, von Bubnoff, Nikolas
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2020
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Research Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7138400/
https://ncbi.nlm.nih.gov/pubmed/31955503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12640
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