Targeting abnormal DNA double strand break repair in cancer

Por Rassool, Feyruz V., Tomkinson, Alan E.
Publicado em 2010

Up-regulation of WRN and DNA ligase IIIα in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks

Por Sallmyr, Annahita, Tomkinson, Alan E., Rassool, Feyruz V.
Publicado em 2008

Oxidative stress leads to increased mutation frequency in a murine model of myelodysplastic syndrome

Por Chung, Yang Jo, Robert, Carine, Gough, Sheryl M., Rassool, Feyruz V., Aplan, Peter D.
Publicado em 2013

Defective nonhomologous end joining blocks B-cell development in FLT3/ITD mice

Por Li, Li, Zhang, Li, Fan, Jinshui, Greenberg, Kathleen, Desiderio, Stephen, Rassool, Feyruz V., Small, Donald
Publicado em 2011

High-Fidelity Reprogrammed Human IPSCs Have a High Efficacy of DNA Repair and Resemble hESCs in Their MYC Transcriptional Signature

Por Nagaria, Pratik K., Robert, Carine, Park, Tea Soon, Huo, Jeffrey S., Zambidis, Elias T., Rassool, Feyruz V.
Publicado no Stem Cells Int (2016)

Aromatase Inhibitor-Mediated Down Regulation of INrf2 (Keap1) Leads to Increased Nrf2 and Resistance in Breast Cancer

Por Khatri, Raju, Shah, Preeti, Guha, Rupa, Rassool, Feyruz V., Tomkinson, Alan E., Brodie, Angela, Jaiswal, Anil K.
Publicado no Mol Cancer Ther (2015)

Targeting abnormal DNA double strand break repair in tyrosine kinase inhibitor-resistant chronic myeloid leukemias

Por Tobin, Lisa A., Robert, Carine, Rapoport, Aaron P., Gojo, Ivana, Baer, Maria R., Tomkinson, Alan E., Rassool, Feyruz V.
Publicado em 2012

Histone deacetylase inhibitors decrease NHEJ both by acetylation of repair factors and trapping of PARP1 at DNA double-strand breaks in chromatin

Por Robert, Carine, Nagaria, Pratik K., Pawar, Nisha, Adewuyi, Adeoluwa, Gojo, Ivana, Meyers, David J., Cole, Philip A., Rassool, Feyruz V.
Publicado no Leuk Res (2016)

Pim kinase inhibition sensitizes FLT3-ITD acute myeloid leukemia cells to topoisomerase 2 inhibitors through increased DNA damage and oxidative stress

Por Doshi, Kshama A., Trotta, Rossana, Natarajan, Karthika, Rassool, Feyruz V., Tron, Adriana E., Huszar, Dennis, Perrotti, Danilo, Baer, Maria R.
Publicado no Oncotarget (2016)

Targeting abnormal DNA repair in therapy-resistant breast cancers

Por Tobin, Lisa A., Robert, Carine, Nagaria, Pratik, Chumsri, Saranya, Twaddell, William, Ioffe, Olga B., Greco, George E., Brodie, Angela H., Tomkinson, Alan E., Rassool, Feyruz V.
Publicado em 2011

Hydroxylated Dimeric Naphthoquinones Increase the Generation of Reactive Oxygen Species, Induce Apoptosis of Acute Myeloid Leukemia Cells and Are Not Substrates of the Multidrug Re...

Por Lapidus, Rena G., Carter-Cooper, Brandon A., Sadowska, Mariola, Choi, Eun Yong, Wonodi, Omasiri, Muvarak, Nidal, Natarajan, Karthika, Pidugu, Lakshmi S., Jaiswal, Anil, Toth, Eric A., Rassool, Feyruz V., Etemadi, Arash, Sausville, Edward A., Baer, Maria R., Emadi, Ashkan
Publicado no Pharmaceuticals (Basel) (2016)

Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile

Por Cramer-Morales, Kimberly, Nieborowska-Skorska, Margaret, Scheibner, Kara, Padget, Michelle, Irvine, David A., Sliwinski, Tomasz, Haas, Kimberly, Lee, Jaewoong, Geng, Huimin, Roy, Darshan, Slupianek, Artur, Rassool, Feyruz V., Wasik, Mariusz A., Childers, Wayne, Copland, Mhairi, Müschen, Markus, Civin, Curt I., Skorski, Tomasz
Publicado em 2013

Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents – A Potential Therapy for Cancer

Por Muvarak, Nidal E., Chowdhury, Khadiza, Xia, Limin, Robert, Carine, Choi, Eun Yong, Cai, Yi, Bellani, Marina, Zou, Ying, Singh, Zeba N., Duong, Vu H., Rutherford, Tyler, Nagaria, Pratik, Bentzen, Søren M., Seidman, Michael M., Baer, Maria R., Lapidus, Rena G., Baylin, Stephen B., Rassool, Feyruz V.
Publicado no Cancer Cell (2016)

Transient Low Doses of DNA Demethylating Agents Exert Durable Anti-tumor Effects on Hematological and Epithelial Tumor Cells

Por Tsai, Hsing-Chen, Li, Huili, Van Neste, Leander, Cai, Yi, Robert, Carine, Rassool, Feyruz V., Shin, James J., Harbom, Kirsten M., Beaty, Robert, Pappou, Emmanouil, Harris, James, Yen, Ray-Whay Chiu, Ahuja, Nita, Brock, Malcolm V., Stearns, Vered, Feller-Kopman, David, Yarmus, Lonny B., Lin, Yi-Chun, Welm, Alana L., Issa, Jean-Pierre, Minn, Il, Matsui, William, Jang, Yoon-Young, Sharkis, Saul J., Baylin, Stephen B., Zahnow, Cynthia A.
Publicado em 2012