Hedgehog signaling in cancer stem cells: a focus on hematological cancers

Por Campbell, Victoria, Copland, Mhairi
Publicado no Stem Cells Cloning (2015)

Defining niche interactions to target chronic myeloid leukemia stem cells

Por Mitchell, Rebecca, Copland, Mhairi
Publicado no Haematologica (2020)

Targeting self-renewal pathways in myeloid malignancies

Por Sands, William A, Copland, Mhairi, Wheadon, Helen
Publicado em 2013

Cell chip array for microfluidic proteomics enabling rapid in situ assessment of intracellular protein phosphorylation

Por Faley, Shannon L., Copland, Mhairi, Reboud, Julien, Cooper, Jonathan M.
Publicado em 2011

Allogeneic stem cell transplantation for chronic myeloid leukaemia is safe and effective in high risk patients following second generation tyrosine kinase inhibitors: A single cent...

Por Latif, Anne-Louise, McQuaker, Grant, Parker, Anne, Clark, Andrew, Copland, Mhairi
Publicado em 2013

Implementing the EffTox dose-finding design in the Matchpoint trial

Por Brock, Kristian, Billingham, Lucinda, Copland, Mhairi, Siddique, Shamyla, Sirovica, Mirjana, Yap, Christina
Publicado no BMC Med Res Methodol (2017)

Effects of Dasatinib on Src kinase activity and downstream intracellular signaling in primitive chronic myelogenous leukemia hematopoietic cells

Por Konig, Heiko, Copland, Mhairi, Chu, Su, Jove, Richard, Holyoake, Tessa L., Bhatia, Ravi
Publicado em 2008

Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal

Por Toofan, Parto, Busch, Caroline, Morrison, Heather, O’Brien, Stephen, Jørgensen, Heather, Copland, Mhairi, Wheadon, Helen
Publicado no Cell Death Dis (2018)

The MEK inhibitor PD184352 enhances BMS-214662-induced apoptosis in CD34+ CML stem/progenitor cells

Por Pellicano, Francesca, Šimara, Pavel, Sinclair, Amy, Helgason, G. Vignir, Copland, Mhairi, Grant, Steven, Holyoake, Tessa Laurie
Publicado em 2011

Combined Population Dynamics and Entropy Modelling Supports Patient Stratification in Chronic Myeloid Leukemia

Por Brehme, Marc, Koschmieder, Steffen, Montazeri, Maryam, Copland, Mhairi, Oehler, Vivian G., Radich, Jerald P., Brümmendorf, Tim H., Schuppert, Andreas
Publicado no Sci Rep (2016)

Heterogeneous leukemia stem cells in myeloid blast phase chronic myeloid leukemia

Por Kinstrie, Ross, Karamitros, Dimitris, Goardon, Nicolas, Morrison, Heather, Hamblin, Mike, Robinson, Lisa, Clark, Richard E., Copland, Mhairi, Vyas, Paresh
Publicado no Blood Adv (2016)

Autocrine TNF-α production supports CML stem and progenitor cell survival and enhances their proliferation

Por Gallipoli, Paolo, Pellicano, Francesca, Morrison, Heather, Laidlaw, Kamilla, Allan, Elaine K., Bhatia, Ravi, Copland, Mhairi, Jørgensen, Heather G., Holyoake, Tessa L.
Publicado em 2013

Consensus on BCR‐ABL1 reporting in chronic myeloid leukaemia in the UK

Por Cross, Nicholas C. P., White, Helen E., Evans, Paul A. S., Hancock, Jeremy, Copland, Mhairi, Milojkovic, Dragana, Mason, Joanne, Craine, Sandra, Mead, Adam J.
Publicado no Br J Haematol (2018)

Developing collaborations to establish a low-cost advanced diagnostic hematology laboratory in Peshawar, Pakistan

Por Yousafzai, Yasar Mehmood, Ahmed, Jawad, Raziq, Fazle, Smith, Amanda, Chudleigh, Sandra, Doig, Allyson, O’Brien, Darren, Williams, Nicola, Leach, Mike, Copland, Mhairi, Halsey, Chris
Publicado no Blood Adv (2017)

DNMT inhibitors reverse a specific signature of aberrant promoter DNA methylation and associated gene silencing in AML

Por Lund, Kirstin, Cole, John J, VanderKraats, Nathan D, McBryan, Tony, Pchelintsev, Nikolay A, Clark, William, Copland, Mhairi, Edwards, John R, Adams, Peter D
Publicado em 2014

The Antiproliferative Activity of Kinase Inhibitors in Chronic Myeloid Leukemia Cells Is Mediated by FOXO Transcription Factors

Por Pellicano, Francesca, Scott, Mary T, Helgason, G Vignir, Hopcroft, Lisa E M, Allan, Elaine K, Aspinall-O'Dea, Mark, Copland, Mhairi, Pierce, Andrew, Huntly, Brian J P, Whetton, Anthony D, Holyoake, Tessa L
Publicado no Stem Cells (2014)

Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia

Por Irvine, David A., Zhang, Bin, Kinstrie, Ross, Tarafdar, Anuradha, Morrison, Heather, Campbell, Victoria L., Moka, Hothri A., Ho, Yinwei, Nixon, Colin, Manley, Paul W., Wheadon, Helen, Goodlad, John R., Holyoake, Tessa L., Bhatia, Ravi, Copland, Mhairi
Publicado no Sci Rep (2016)

CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy

Por Kinstrie, Ross, Horne, Gillian A., Morrison, Heather, Irvine, David, Munje, Chinmay, Castañeda, Eduardo Gómez, Moka, Hothri A., Dunn, Karen, Cassels, Jennifer E., Parry, Narissa, Clarke, Cassie J., Scott, Mary T., Clark, Richard E., Holyoake, Tessa L., Wheadon, Helen, Copland, Mhairi
Publicado no Leukemia (2020)

Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile

Por Cramer-Morales, Kimberly, Nieborowska-Skorska, Margaret, Scheibner, Kara, Padget, Michelle, Irvine, David A., Sliwinski, Tomasz, Haas, Kimberly, Lee, Jaewoong, Geng, Huimin, Roy, Darshan, Slupianek, Artur, Rassool, Feyruz V., Wasik, Mariusz A., Childers, Wayne, Copland, Mhairi, Müschen, Markus, Civin, Curt I., Skorski, Tomasz
Publicado em 2013

Dual targeting of p53 and c-Myc selectively eliminates leukaemic stem cells

Por Abraham, Sheela A, Hopcroft, Lisa EM, Carrick, Emma, Drotar, Mark E, Dunn, Karen, Williamson, Andrew JK, Korfi, Koorosh, Baquero, Pablo, Park, Laura E, Scott, Mary T, Pellicano, Francesca, Pierce, Andrew, Copland, Mhairi, Nourse, Craig, Grimmond, Sean M, Vetrie, David, Whetton, Anthony D, Holyoake, Tessa L
Publicado no Nature (2016)