Autocrine TNF-α production supports CML stem and progenitor cell survival and enhances their proliferation

Chronic myeloid leukemia (CML) stem cells are not dependent on BCR-ABL kinase for their survival, suggesting that kinase-independent mechanisms must contribute to their persistence. We observed that CML stem/progenitor cells (SPCs) produce tumor necrosis factor-α (TNF-α) in a kinase-independent fash...

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Detalhes bibliográficos
Main Authors: Gallipoli, Paolo, Pellicano, Francesca, Morrison, Heather, Laidlaw, Kamilla, Allan, Elaine K., Bhatia, Ravi, Copland, Mhairi, Jørgensen, Heather G., Holyoake, Tessa L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953090/
https://ncbi.nlm.nih.gov/pubmed/24041577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-02-485607
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