Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt–β-catenin signaling

Tyrosine kinase inhibitors (TKIs) are highly effective in treatment of chronic myeloid leukemia (CML) but do not eliminate leukemia stem cells (LSCs), which remain a potential source of relapse. TKI treatment effectively inhibits BCR-ABL kinase activity in CML LSCs, suggesting that additional kinase...

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Detalhes bibliográficos
Main Authors: Zhang, Bin, Li, Min, McDonald, Tinisha, Holyoake, Tessa L., Moon, Randall T., Campana, Dario, Shultz, Leonard, Bhatia, Ravi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591802/
https://ncbi.nlm.nih.gov/pubmed/23299311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-02-412890
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