Enhanced targeting of CML stem and progenitor cells by inhibition of porcupine acyltransferase in combination with TKI

Tyrosine kinase inhibitor (TKI) treatment of chronic myeloid leukemia (CML) has limited efficacy against leukemia stem cells (LSC) responsible for disease propagation, and most CML patients require continued TKI treatment to maintain remission. LSC maintenance is related, at least in part, to signal...

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Publicado en:Blood
Main Authors: Agarwal, Puneet, Zhang, Bin, Ho, Yinwei, Cook, Amy, Li, Ling, Mikhail, Fady M., Wang, Youzhen, McLaughlin, Margaret E., Bhatia, Ravi
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2017
Assuntos:
Myeloid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5324714/
https://ncbi.nlm.nih.gov/pubmed/28011678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-05-714089
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