Osteoblast ablation reduces normal long-term hematopoietic stem cell self-renewal but accelerates leukemia development

Hematopoietic stem cells (HSCs) reside in regulatory niches in the bone marrow (BM). Although HSC niches have been extensively characterized, the role of endosteal osteoblasts (OBs) in HSC regulation requires further clarification, and the role of OBs in regulating leukemic stem cells (LSCs) is not...

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Bibliografske podrobnosti
izdano v:Blood
Main Authors: Bowers, Marisa, Zhang, Bin, Ho, Yinwei, Agarwal, Puneet, Chen, Ching-Cheng, Bhatia, Ravi
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2015
Teme:
Myeloid Neoplasia
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408292/
https://ncbi.nlm.nih.gov/pubmed/25742698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-06-582924
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