Osteoblast ablation reduces normal long-term hematopoietic stem cell self-renewal but accelerates leukemia development

Hematopoietic stem cells (HSCs) reside in regulatory niches in the bone marrow (BM). Although HSC niches have been extensively characterized, the role of endosteal osteoblasts (OBs) in HSC regulation requires further clarification, and the role of OBs in regulating leukemic stem cells (LSCs) is not...

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Dades bibliogràfiques
Publicat a:Blood
Autors principals: Bowers, Marisa, Zhang, Bin, Ho, Yinwei, Agarwal, Puneet, Chen, Ching-Cheng, Bhatia, Ravi
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2015
Matèries:
Myeloid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408292/
https://ncbi.nlm.nih.gov/pubmed/25742698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-06-582924
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