Enhanced targeting of CML stem and progenitor cells by inhibition of porcupine acyltransferase in combination with TKI

Tyrosine kinase inhibitor (TKI) treatment of chronic myeloid leukemia (CML) has limited efficacy against leukemia stem cells (LSC) responsible for disease propagation, and most CML patients require continued TKI treatment to maintain remission. LSC maintenance is related, at least in part, to signal...

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Bibliografiset tiedot
Julkaisussa:Blood
Päätekijät: Agarwal, Puneet, Zhang, Bin, Ho, Yinwei, Cook, Amy, Li, Ling, Mikhail, Fady M., Wang, Youzhen, McLaughlin, Margaret E., Bhatia, Ravi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Hematology 2017
Aiheet:
Myeloid Neoplasia
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5324714/
https://ncbi.nlm.nih.gov/pubmed/28011678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-05-714089
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