Enhanced targeting of CML stem and progenitor cells by inhibition of porcupine acyltransferase in combination with TKI

Tyrosine kinase inhibitor (TKI) treatment of chronic myeloid leukemia (CML) has limited efficacy against leukemia stem cells (LSC) responsible for disease propagation, and most CML patients require continued TKI treatment to maintain remission. LSC maintenance is related, at least in part, to signal...

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Veröffentlicht in:Blood
Hauptverfasser: Agarwal, Puneet, Zhang, Bin, Ho, Yinwei, Cook, Amy, Li, Ling, Mikhail, Fady M., Wang, Youzhen, McLaughlin, Margaret E., Bhatia, Ravi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2017
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5324714/
https://ncbi.nlm.nih.gov/pubmed/28011678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-05-714089
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