Epigenetic regulators as promising therapeutic targets in acute myeloid leukemia

Por Gallipoli, Paolo, Giotopoulos, George, Huntly, Brian J.P.
Publicado no Ther Adv Hematol (2015)

Autocrine TNF-α production supports CML stem and progenitor cell survival and enhances their proliferation

Por Gallipoli, Paolo, Pellicano, Francesca, Morrison, Heather, Laidlaw, Kamilla, Allan, Elaine K., Bhatia, Ravi, Copland, Mhairi, Jørgensen, Heather G., Holyoake, Tessa L.
Publicado em 2013

JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34(+) cells in vitro and in vivo

Por Gallipoli, Paolo, Cook, Amy, Rhodes, Susan, Hopcroft, Lisa, Wheadon, Helen, Whetton, Anthony D., Jørgensen, Heather G., Bhatia, Ravi, Holyoake, Tessa L.
Publicado em 2014

CML cells actively evade host immune surveillance through cytokine-mediated downregulation of MHC-II expression

Por Tarafdar, Anuradha, Hopcroft, Lisa E. M., Gallipoli, Paolo, Pellicano, Francesca, Cassels, Jennifer, Hair, Alan, Korfi, Koorosh, Jørgensen, Heather G., Vetrie, David, Holyoake, Tessa L., Michie, Alison M.
Publicado no Blood (2017)

A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression

Por Giotopoulos, George, van der Weyden, Louise, Osaki, Hikari, Rust, Alistair G., Gallipoli, Paolo, Meduri, Eshwar, Horton, Sarah J., Chan, Wai-In, Foster, Donna, Prinjha, Rab K., Pimanda, John E., Tenen, Daniel G., Vassiliou, George S., Koschmieder, Steffen, Adams, David J., Huntly, Brian J.P.
Publicado no J Exp Med (2015)

Targeting Primitive Chronic Myeloid Leukemia Cells by Effective Inhibition of a New AHI-1–BCR-ABL–JAK2 Complex

Por Chen, Min, Gallipoli, Paolo, DeGeer, Donna, Sloma, Ivan, Forrest, Donna L., Chan, Matthew, Lai, Damian, Jorgensen, Heather, Ringrose, Ashley, Wang, Hui Mi, Lambie, Karen, Nakamoto, Helen, Saw, Kyi Min, Turhan, Ali, Arlinghaus, Ralph, Paul, James, Stobo, Jon, Barnett, Michael J., Eaves, Allen, Eaves, Connie J, Holyoake, Tessa L., Jiang, Xiaoyan
Publicado em 2013

A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia

Por Tzelepis, Konstantinos, Koike-Yusa, Hiroko, De Braekeleer, Etienne, Li, Yilong, Metzakopian, Emmanouil, Dovey, Oliver M., Mupo, Annalisa, Grinkevich, Vera, Li, Meng, Mazan, Milena, Gozdecka, Malgorzata, Ohnishi, Shuhei, Cooper, Jonathan, Patel, Miten, McKerrell, Thomas, Chen, Bin, Domingues, Ana Filipa, Gallipoli, Paolo, Teichmann, Sarah, Ponstingl, Hannes, McDermott, Ultan, Saez-Rodriguez, Julio, Huntly, Brian J.P., Iorio, Francesco, Pina, Cristina, Vassiliou, George S., Yusa, Kosuke
Publicado no Cell Rep (2016)